Mhedzisiro yechidzidzo chitsva chakabudiswa mumagazini yeBiomed Central BMC yakaratidza kuti turmeric yakatorwa yakashanda separacetamol mukuderedza marwadzo uye zvimwe zviratidzo zvebvi osteoarthritis (OA). Chidzidzo chacho chakaratidza kuti bioavailable compound yainyanya kushanda mukuderedza kuzvimba.
Osteoarthritis chirwere chinopera chezvikamu zve articular chinoratidzwa nekuputsika kwekashwa, majoini ekubatanidza, ligaments, uye pasi pebhonzo. Zvinowanzoitika zviratidzo zve osteoarthritis kuoma uye kurwadziwa.
Inotungamirwa naShuba Singhal, PhD, iyi yakasarudzika, inodzorwa yekiriniki yekudzidza yakaitwa paDhipatimendi reOrthopedics reLok Nayak Jai Prakash Hospital/Maulana Azad Medical College, New Delhi. Pachidzidzo ichi, varwere ve193 vakaonekwa kuti vane osteoarthritis yemabvi vakangoerekana vagamuchira kana turmeric extract (BCM-95) se 500 mg capsule kaviri pazuva, kana 650 mg piritsi yeparacetamol katatu zuva nezuva kwemavhiki matanhatu.
Knee arthritis zviratidzo zvekurwadziwa, kuoma kwemajoini, uye kushomeka kwekuita kwemuviri kwakaongororwa pachishandiswa Western Ontario uye McMaster Universities Osteoarthritis Index (WOMAC). Mushure memavhiki matanhatu ekurapwa, kuongororwa kwevanopindura kwakaratidza kuvandudzwa kukuru muWOMAC zvibodzwa pamativi ese anoenzaniswa neboka reparacetamol, ne18% yeboka reBCM-95 rinoshuma 50% kuvandudzwa, uye 3% yezvidzidzo zvichiona 70% kuvandudzwa.
Migumisiro iyi yakaratidzwa zvakanaka muboka reBCM-95 serum inflammatory markers: CRP mazinga akaderedzwa ne 37.21%, uye TNF-α mazinga akachekwa ne74.81%, zvichiratidza BCM-95 yakaita zviri nani kupfuura paracetamol.
Chidzidzo ichi chaive chekutevera kuongororo yeArjuna yakaitwa kwegore rapfuura iyo yakaratidza kubatana kwakanaka pakati peiyo flagship curcumin kuumbwa uye osteoarthritic care.
"Chinangwa chechidzidzo chezvino chaive chekuvaka pane zvidzidzo zvekare kuti zvipe kujeka kuri nani uye kujekeswa nekubatanidza mamakisi akawanda uye nzira yekukora iri nani," akadaro Benny Antony, maneja maneja director weArjuna. "Iyo anti-arthritic mhedzisiro yeBCM-95 muosteoarthritis inoratidzwa nekugona kwayo kugadzirisa anti-inflammatory markers TNF neCRP."
Knee OA ndiyo inotungamira honzeri yekuremara uye kurwadziwa pakati pevakuru nevakwegura. Inofungidzirwa kuti gumi kusvika gumi neshanu muzana yevakuru vese vanopfuura makore makumi matanhatu vane mwero weOA, uye kupararira kwakanyanya pakati pevakadzi kupfuura varume.
"Ongororo iyi inosimbisa zvakare anti-arthritic maitiro eBCM-95 uye inopa tariro yamutsidzirwa kumamirioni ekuvandudza hupenyu hwavo," akadaro Nipen Lavingia, chipangamazano chemhando yeArjuna Natural muDallas, TX.
"Tiri kudzidza zvakawanda nezve nzira dziri kumashure kwecurcumin's anti-inflammatory effect yatinotenda imhaka yekugona kwayo kuvharidzira zviratidzo zvepro-inflammatory, senge prostaglandins, leukotrienes, uye cyclooxygenase-2. Pamusoro pezvo, curcumin yakaratidza kudzvanya akati wandei e-pro-inflammatory cytokines uye varevereri vekusunungurwa kwavo, senge tumor necrosis factor-α (TNF-α), IL-1, IL-8, uye nitric oxide synthase, "akadaro Antony.
BCM-95's yakasarudzika fusion ye curcuminoids uye turmerone-yakapfuma yakakosha maoiri enhengo inokunda curcumin's hunhu bioavailability zvipingamupinyi nekuda kwehunhu hwayo hwepamusoro lipophilic.
Nguva yekutumira: Kubvumbi-12-2021